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Through paracrine/autocrine mechanisms, EPO signaling subsequently activates and upregulates efferocytosis-related molecules via peroxisome proliferator-activated receptor gamma (PPARg) activation, including Mer tyrosine kinase (MerTK) and growth arrest-specific 6 (Gas6), among others, thus priming the cells for efficient efferocytosis (Poon and Ravichandran, 2024)

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This accumulation suggests that methoxylated scaffolds contribute to pathogen-responsive defense

Concentrations are highest in youth (around 200 ng/mL in young adults) and decline with age to approximately 80 ng/mL by age 60

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